Soylu-Kucharz R, Khoshnan A and Petersén Å. bioRxiv 2021.04.08.438894; First published April 9, 2021. https://doi.org/10.1101/2021.04.08.438894 Abstract Background Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, and underlying mechanisms are not fully known. As the IKKβ/NF

https://www.huntington-research.lu.se/ikkb-signaling-mediates-metabolic-changes-hypothalamus-huntingtons-disease-mouse-model - 2025-01-25

Henningsen JB,  Soylu-Kucharz R, Björkqvist M and Petersén Å. Heliyon. 2021 Aug 14;7(8):e07808. doi: 10.1016/j.heliyon.2021.e07808. eCollection 2021 Aug. Abstract Huntington disease (HD) is a fatal neurodegenerative movement disorder caused by an expanded CAG repeat in the huntingtin gene (HTT). The mutant huntingtin protein is ubiquitously expressed, but only certain brain regions are affected. T

https://www.huntington-research.lu.se/effects-excitotoxicity-hypothalamus-transgenic-mouse-models-huntington-disease - 2025-01-25

Learn more from these short films where Åsa Petersén talks about cognitive symptoms and behavioural changes and psychiatric in Huntington's disease. Published by courtesy of Riksförbundet Huntingtons Sjukdom. All films are in Swedish. To view the Swedish subtitles, please click the button "CC" in the control bar (third from right) and choose "Svenska". Åsa Petersén about cognitive symptoms.   Åsa

https://www.huntington-research.lu.se/cognitive-symptoms-and-behavioural-changes - 2025-01-25

Gabery S, Kwa JE, Cheong RY, Baldo B, Ferrari Bardile C, Tan B, McLean C, Georgiou-Karistianis N, Poudel GR, Halliday G, Pouladi MA and Petersén Å.  Acta Neuropathologica. 142(5): 791-806 (2021) doi: 10.1007/s00401-021-02362-8. Abstract Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. The typical motor symptoms have been a

https://www.huntington-research.lu.se/early-white-matter-pathology-fornix-limbic-system-huntington-disease - 2025-01-25

Hyrskyluoto A, Bruelle C, Lundh SH, Do HT, Kivinen J, Rappou E, Reijonen S, Waltimo T, Petersén Å, Lindholm D and Korhonen L.Human Molecular Genetics 23: 5928-5939 (2014)AbstractHuntington's disease (HD) is an autosomal inherited neurological disease caused by a CAG repeat expansion in the first exon of huntingtin gene encoding for the huntingtin protein (Htt). In HD there is an accumulation of in

https://www.huntington-research.lu.se/ubiquitin-specific-protease-14-reduces-cellular-aggregates-and-protects-against-mutant-huntingtin - 2025-01-25

Dickson E, Soylu-Kucharz R , Petersén Å and Björkqvist M. Mol Metab. 2022 Mar;57:101439. doi: 10.1016/j.molmet.2022.101439. Epub 2022 Jan 7. Abstract Objective In Huntington's disease (HD), the disease-causing huntingtin (HTT) protein is ubiquitously expressed and causes both central and peripheral pathology. In clinical HD, a higher body mass index has been associated with slower disease progress

https://www.huntington-research.lu.se/hypothalamic-expression-huntingtin-causes-distinct-metabolic-changes-huntingtons-disease-mice - 2025-01-25

Soylu-Kucharz R, Khoshnan A and Petersén Å. iScience 2022 Jan 19;25(2):103771. doi: 10.1016/j.isci.2022.103771. eCollection 2022 Feb 18. Abstract Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, but underlying mechanisms are not fully known. As the IKKβ/NF-κB pathway is an

https://www.huntington-research.lu.se/ikkb-signaling-mediates-metabolic-changes-hypothalamus-huntingtons-disease-mouse-model-0 - 2025-01-25

Dickson E, Sai Dwijesha A, Andersson N, Lundh S, Björkqvist M, Petersén Å and Soylu-Kucharz R. Frontiers in Neuroscience. 2022 Nov 3;16:1027269. doi: 10.3389/fnins.2022.1027269. PMID: 36408416; PMCID: PMC9671106. Abstract Structural changes and neuropathology in the hypothalamus have been suggested to contribute to the non-motor manifestations of Huntington’s disease (HD), a neurodegenerative diso

https://www.huntington-research.lu.se/microarray-profiling-hypothalamic-gene-expression-changes-huntingtons-disease-mouse-models - 2025-01-25

Petersén Å1 and Kirik D2.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.2Brain Repair and Imaging in Neural Systems (BRAINS) Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.Journal of Clinical Investigation 17:1-3 (2014)AbstractA common form of the hyperkinetic movement disor

https://www.huntington-research.lu.se/twisting-mice-move-dystonia-field-forward - 2025-01-25

Hellem MNN, Cheong RY, Tonetto S, Vinther-Jensen T, Hendel RK, Larsen IU, Nielsen TT, Hjermind LE, Vogel A, Budtz-Jørgensen E, Petersén Å and Nielsen JE. Parkinsonism and Related Disorders. 99: 23-29 (2022).  Abstract Objective: Huntington's disease (HD) is an inherited neurodegenerative disease with motor, cognitive and psychiatric symptoms. Non-motor symptoms like depression and altered social c

https://www.huntington-research.lu.se/decreased-csf-oxytocin-relates-measures-social-cognitive-impairment-huntingtons-disease-patients - 2025-01-25

Bergh S, Cheong R Y, Petersén Å and Gabery S. Front. Mol. Neurosci., 14 September 2022; Sec. Molecular Signalling and Pathways; doi.org/10.3389/fnmol.2022.984317   Abstract Neurodegenerative disorders (NDDs) such as Huntington’s disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by progressive loss of selectively vulnerable popu

https://www.huntington-research.lu.se/oxytocin-huntingtons-disease-and-spectrum-amyotrophic-lateral-sclerosis-frontotemporal-dementia - 2025-01-25

Furby H, Moore S, Nordstroem A-L, Houghton R, Lambrelli D, Graham S, Svenningsson P and Petersén Å. Journal of Neurology. 270(2): 864-876 (2023) doi:10.1007/s00415-022-11418-y. Abstract Background: Huntington's disease (HD) is a rare, neurodegenerative disease and its complex motor, cognitive and psychiatric symptoms exert a lifelong clinical burden on both patients and their families. Objective:

https://www.huntington-research.lu.se/comorbidities-and-clinical-outcomes-adult-and-juvenile-onset-huntingtons-disease-study-linked - 2025-01-25

The Nordic Centre in India has an India Liaison office in Delhi and a Secretariat that circulates between the member universities in the Nordic region.   The Nordic Centre in India (NCI) is a consortium of leading universities and research institutions in Denmark, Finland, Iceland, Norway, and Sweden. Established in 2001 with the objective to facilitate cooperation in research and higher education

https://www.sasnet.lu.se/networks/nordic-centre-india-nci - 2025-01-25

The Network for Asian Studies (Asianettverket) is based at the Centre for Development and the Environment (SUM) at the University of Oslo, Norway. Asianettverket is a Norwegian research network promoting studies and research on Asia, and sharing knowledge about the region's history, society, culture, politics and the environment. The network was founded in 1996 and is led by a group of scholars in

https://www.sasnet.lu.se/networks/asianettverket - 2025-01-25

In his newly published report "From Afghanistan to Syria: The Development of the Theological and Political Aspects of Jihadi-Salafism", funded by SASNET and the Centre for Advanced Middle Eastern Studies at Lund University, researcher Orwa Ajjoub interrogates the complicated relationship between the theological concepts of jihadi-Salafism and the ever-changing socio-political context in which they

https://www.sasnet.lu.se/research/publications/sasnet-reports/development-theological-and-political-aspects-jihadi-salafism - 2025-01-25

  In her report "Education as an empowerment tool for women in Afghanistan: the insider perspectives of educated Afghan women", which is a summary of her MA thesis, author Maliha Shir Mohammad explores the understudied topic of the lived experiences of educated Afghan women and investigates their perspectives on education as an empowerment tool, in addition to their challenges and motivations for

https://www.sasnet.lu.se/research/publications/sasnet-reports/education-empowerment-tool-women-afghanistan - 2025-01-25

  Abstract: This is a preliminary pilot project that encompasses an overview on the Indo-Bangladeshi complex borderlands, focusing on the enclaves or ‘chitmahals’ that became unique stateless conflict zones between India and Bangladesh. A historic Land Boundary Agreement was signed in 2015, that officially exchanged all chitmahals of both Indian and Bangladeshi side towards incorporation and inclu

https://www.sasnet.lu.se/research/publications/sasnet-reports/fuzzy-borders-and-postcolonial-forgotten-zones-case-indo-bangladeshi-enclaves - 2025-01-25

This website is run by SASNET. We want as many people as possible to be able to use this website, and this document describes how www.sasnet.lu.se complies with the accessibility regulations, any known accessibility issues, and how you can report problems so that we can fix them. How accessible is www.sasnet.lu.se? We know some parts of this website aren't fully accessible. See the section on non-

https://www.sasnet.lu.se/accessibility-statement - 2025-01-25

From June 2021 to February 2022 This project focused on historical ruptures within the Indian nation since the Partition of 1947, 1971 and the present moment that includes the long Kashmir conflict as a painful legacy of the colonial border alignments and construction of the two nation-states. It raises questions on belonging and and the idea of citizenship in its creation of the ‘other’ within th

https://www.sasnet.lu.se/nation-and-its-fault-lines - 2025-01-25

RESEARCHER Dr. Amrita Ghosh was a researcher at SASNET with the project "A Nation and its Fault Lines", from June 2021 to February 2022. She has worked on a postdoc at Linnaeus University, Center of Concurrences in Colonial and Postcolonial Studies. During the postdoc she worked on emerging literature, films and visual texts on and from Kashmir, representing the conflict in myriad ways. Her monogr

https://www.sasnet.lu.se/staff/amrita-ghosh - 2025-01-25